Potassium Carbonate → 4-Methoxy-3-propoxybenzaldehyde

HRID 1990800Notes

Reaction equation

HRID 1990800 reaction equation
[O:1]=[CH:2][C:3]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:5]([OH:6])[CH:4]=1.[CH2:12](I)[CH2:13][CH3:14].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH3:9][O:8][C:7]1[CH:10]=[CH:11][C:3]([CH:2]=[O:1])=[CH:4][C:5]=1[O:6][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12127IsovanillinHCID 336431-Iodopropane

Product 1

HCID 5921094-Methoxy-3-propoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared by reaction of isovanillin with propyl iodide in DMF with K2CO3 as base as described in M. J. Ashton, D. C. Cook, G. Fenton, J.-A. Karlsson, M. N. Palfreyman, D. Raeburn, A. J. Ratcliffe, J. E. Souness, S. Thurairatnam, N. Vicker J. Med. Chem. 1994, 37, 1696-1703.

Sources & evidence

ORD record
ord-65410d4c44f74ca28331c9f45e06b2a9
Source dataset
uspto-grants-2010_01
Patent number
US07645753B2

Reaction notes

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