Hydrochloric Acid → HCID 68681026, compound

HRID 1992748Notes

Reaction equation

HRID 1992748 reaction equation
[CH3:1][C:2](=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][NH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:28]=[C:29]([O:33][CH3:34])[C:30]=1[O:31][CH3:32])[C:25](O)=[O:26].F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1.Cl>C(N(CC)CC)C>[CH3:34][O:33][C:29]1[CH:28]=[C:24]([CH:23]=[C:22]([O:21][CH3:20])[C:30]=1[O:31][CH3:32])[C:25]([N:4]([CH2:3][C:2]([CH3:1])=[CH:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:26]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 83573,4,5-Trimethoxybenzoic AcidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 68682291HCID 68682291, compound

Product 1

HCID 68681026HCID 68681026, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Experimental condition analogous to Example 13 were used with (2-Methyl-3-phenyl-allyl)-(2-piperidin-1-yl-ethyl)-amine, 0.5 g (1.9 mmol), 3,4,5-trimethoxy benzoic acid 0.49 g (2.3 mmol), 0.2 ml of triethylamine, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate 1.2 g (3.8 mmol). The reaction yielded 102 mg of an off-white solid as an HCl salt. Yield: 12%.

Sources & evidence

ORD record
ord-1644c9d6be684e23b6c7a8c0cc86764b
Source dataset
uspto-grants-2010_01
Patent number
US07649011B2

Reaction notes

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