Trifluoroacetic acid → HCID 72524890, compound

HRID 1992753Notes

Reaction equation

HRID 1992753 reaction equation
[Br:1][C:2](=[CH:18][C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)[CH2:3][NH:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:34]=[C:35]([O:39][CH3:40])[C:36]=1[O:37][CH3:38])[C:31](Cl)=[O:32].C(N(CC)CC)C.C(O)(C(F)(F)F)=O>C(#N)C>[Br:1][C:2](=[CH:18][C:19]1[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=1)[CH2:3][N:4]([CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:31](=[O:32])[C:30]1[CH:29]=[C:28]([O:27][CH3:26])[C:36]([O:37][CH3:38])=[C:35]([O:39][CH3:40])[CH:34]=1

Participants

6

Reactant 4

HCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 72524915HCID 72524915, compound

Product 1

HCID 72524890HCID 72524890, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Experimental condition analogous to Example 12 were used with [2-bromo-3-(4-fluoro-phenyl)-allyl]-(1-cyclohexylmethyl-pyrrolidin-2-ylmethyl)-amine 0.15 g (0.36 mmol), 3,4,5-trimethoxy-benzoylchloride 0.1 g (0.47 mmol), and triethylamine 0.08 ml. Reverse phase high pressure liquid chromatography with a gradient of 20-80% acetonitrile phase lead to 120 mg of white powder as a TFA salt.

Sources & evidence

ORD record
ord-6600dec538da4a8dabd261c03a8ad9b0
Source dataset
uspto-grants-2010_01
Patent number
US07649011B2

Reaction notes

Loading…