反应详情

温度

100 °C

Add potassium hydroxide (486.7 mmol, 32.1 g) over a solution of 2,3-dihydroxy-2-methyl-propionic acid (423.2 mmol, 50 g) in 300 mL of DMF. Stir the solution for 1 hour at 100° C., then add benzyl bromide. Stir the solution overnight. Cool the mixture and dilute with ethyl acetate. Wash organic layer with water. Wash aqueous layer with ethyl acetate several times. Combine organic layers and dry over sodium sulfate, filter and concentrate under reduced pressure.

1. stirringStir the solution overnight
2. temperatureCool the mixture
3. dry with materialCombine organic layers and dry over sodium sulfate
4. filtrationfilter
5. concentrationconcentrate under reduced pressure