Glycidol → HCID 20487788, compound

HRID 1995725Notes

Reaction equation

HRID 1995725 reaction equation
[CH3:1][C:2]1([CH:17]([CH3:19])[CH3:18])[C:6](=[O:7])[NH:5][C:4]2([CH2:12][C:11]([CH3:14])([CH3:13])[NH:10][C:9]([CH3:16])([CH3:15])[CH2:8]2)[O:3]1.[CH2:20]1[O:22][CH:21]1[CH2:23][OH:24]>C(O)CCCCC.Cl>[CH3:1][C:2]1([CH:17]([CH3:19])[CH3:18])[C:6](=[O:7])[NH:5][C:4]2([CH2:8][C:9]([CH3:16])([CH3:15])[N:10]([CH2:20][CH:21]([OH:22])[CH2:23][OH:24])[C:11]([CH3:14])([CH3:13])[CH2:12]2)[O:3]1

Participants

5

Reactant 2

HCID 11164GlycidolHCID 20487780HCID 20487780, compound

Product 1

HCID 20487788HCID 20487788, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 81031-HexanolSolvent

Procedure

26.8 g (0.1 mole) of 2,7,7,9,9-pentamethyl-2-isopropyl-1-oxa-4,8-diaza-spiro[4.5]decan-3-one and 7.4 g (0.1 mole) of glycidol in 60 ml of hexanol were stirred for 65 hours at 140° C. in a stirring apparatus, using as catalyst 3 drops of concentrated HCl. The mixture was then evaporated on a rotary evaporator and the residue was recrystallized from xylene/methanol.

Workup

  1. customThe mixture was then evaporated on a rotary evaporator
  2. customthe residue was recrystallized from xylene/methanol

Sources & evidence

ORD record
ord-b6a1ea2decb346ef92074c3ef97a47dd
Source dataset
uspto-grants-1983_09
Patent number
US04405735

Reaction notes

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