Triethylsilicon → 1-Oxoisoindoline-4-carbaldehyde

HRID 2001725Notes

Reaction equation

HRID 2001725 reaction equation
CC[SiH](CC)CC.[O:1]=[CH:2]N1S(=O)(=O)c(c2C1=O)cccc2.Br[c:3]1[c:12]([c:7]2[cH:6][cH:5][cH:4]1)[CH2:11][NH:10][C:8]2=[O:9]>>[O:1]=[CH:2][c:3]1[c:12]([c:7]2[cH:6][cH:5][cH:4]1)[CH2:11][NH:10][C:8]2=[O:9]

Participants

9

Reactant 3

HCID 6327258TriethylsiliconHCID 219075094-Bromoisoindolin-1-oneHCID 546716891,1,3-Trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazole-2-carbaldehyde

Product 1

HCID 722138121-Oxoisoindoline-4-carbaldehyde

Reagents, catalysts & solvents 5

HCID 516892Sodium BicarbonateReagentHCID 167845palladium(II) acetateCatalystHCID 178454889HCID 178454889, compoundCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-ea404d3dffc24bb592fab37f1283e64b
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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