Bicyclo(1.1.1)pentan-1-amine → HCID 178508730, compound

HRID 2002231Notes

Reaction equation

HRID 2002231 reaction equation
[NH2:1][c:2]1[c:7]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([c:16]3[n:28][c:20]([O:21][CH2:22][C@@H:23]4[O:27][CH2:26][CH2:25][CH2:24]4)[n:19][c:18](Cl)[cH:17]3)[CH2:12][CH2:11]2)[cH:6][n:5][cH:4][n:3]1.[NH2:29][C:30]1([CH2:34][CH:32]2[CH2:31]1)[CH2:33]2>>[NH2:1][c:2]1[c:7]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([c:16]3[n:28][c:20]([O:21][CH2:22][C@@H:23]4[O:27][CH2:26][CH2:25][CH2:24]4)[n:19][c:18](C([NH:29][C:30]5([CH2:34][CH:32]6[CH2:31]5)[CH2:33]6)=O)[cH:17]3)[CH2:12][CH2:11]2)[cH:6][n:5][cH:4][n:3]1

Participants

8

Reactant 2

HCID 11469065Bicyclo(1.1.1)pentan-1-amineHCID 178508729HCID 178508729, compound

Product 1

HCID 178508730HCID 178508730, compound

Reagents, catalysts & solvents 5

HCID 81531DiisopropylethylamineReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 887MethanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-4689d7566e0c4fabb09fe5dd384bc99d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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