Methanol → HCID 178498027, compound

HRID 2002469Notes

Reaction equation

HRID 2002469 reaction equation

[CH3:1][CH:2]([c:12]1[c:18]([Cl:19])[c:16]([F:17])[cH:15][cH:14][c:13]1Br)[O:3][c:4]2[c:10]([NH2:11])[n:9][cH:8][c:6]([Br:7])[cH:5]2>>COC([c:13]1[c:12]([CH:2]([O:3][c:4]2[c:10]([NH2:11])[n:9][cH:8][c:6]([Br:7])[cH:5]2)[CH3:1])[c:18]([Cl:19])[c:16]([F:17])[cH:15][cH:14]1)=O

Participants

8

Reactant 2

HCID 887Methanol

HCID 178462220HCID 178462220, compound

Product 1

HCID 178498027HCID 178498027, compound

Reagents, catalysts & solvents 5

HCID 81531DiisopropylethylamineReagent

HCID 167845palladium(II) acetateCatalyst

HCID 117064364Ferrocene, 1-[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-2-[(1R)-1-(dicyclohexylphosphino)ethyl]-, (1R)-Catalyst

HCID 887MethanolSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-2e7488d97bd449109154913f25c07054
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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