(R)-(-)-2-Amino-1-propanol → HCID 121408979, compound

HRID 2002527Notes

Reaction equation

HRID 2002527 reaction equation
[CH3:1][O:2][CH2:3][C@H:4]([O:6][c:7]1[n:12][c:11]([N:13]2[CH2:18][CH2:17][CH:16]([c:19]3[c:28]([c:22]4[nH:21][cH:20]3)[c:26]([O:27]C)[cH:25][cH:24][n:23]4)[CH2:15][CH2:14]2)[cH:10][c:9](Cl)[n:8]1)[CH3:5].[CH3:29][C@H:30]([CH2:32][OH:33])[NH2:31]>>[CH3:1][O:2][CH2:3][C@H:4]([O:6][c:7]1[n:8][c:9]([C:10]([NH:31][C@@H:30]([CH2:32][OH:33])[CH3:29])=[O:27])n[c:11]([N:13]2[CH2:18][CH2:17][CH:16]([c:19]3[c:28]([c:22]4[nH:21][cH:20]3)[cH:26][cH:25][cH:24][n:23]4)[CH2:15][CH2:14]2)[n:12]1)[CH3:5]

Participants

8

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 121409575HCID 121409575, compound

Product 1

HCID 121408979HCID 121408979, compound

Reagents, catalysts & solvents 5

HCID 81531DiisopropylethylamineReagentHCID 812191,3-Bis(diphenylphosphino)propaneCatalystHCID 167845palladium(II) acetateCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-c5eed25824464172996ec1e096af9573
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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