2-(Bromomethyl)pyridine hydrobromide → 2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide
Reaction equation
[NH2:1][c:2]1[s:18][c:5]([CH2:6][C@@H:7]2[CH2:11][C@H:10]([c:12]3[s:17][c:15]([NH2:16])[n:14][n:13]3)[CH2:9][CH2:8]2)[n:4][n:3]1.Br.Br[CH2:19][c:20]1[n:25][cH:24][cH:23][cH:22][cH:21]1>>O=C([NH:1][c:2]1[s:18][c:5]([CH2:6][C@@H:7]2[CH2:11][C@H:10]([c:12]3[s:17][c:15]([NH:16]C(Cc4ncccc4)=O)[n:14][n:13]3)[CH2:9][CH2:8]2)[n:4][n:3]1)[CH2:19][c:20]5[n:25][cH:24][cH:23][cH:22][cH:21]5Participants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 110 °C
Sources & evidence
- ORD record
- ord-837a4adad12c4671bdcd65dc93c4976a
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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