Tert-Butyl isocyanide → HCID 178440944, compound

HRID 2002887Notes

Reaction equation

HRID 2002887 reaction equation
C[C:1]([N+]#[C-])(C)C.Br[Zn][CH2:2][CH2:3][c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1.[CH3:10][C:11]([c:14]1[n:19][cH:18][c:17](Br)[cH:16][cH:15]1)([CH3:13])[CH3:12]>>[CH3:10][C:11]([c:14]1[n:19][cH:18][c:17]([C:1]([CH2:2][CH2:3][c:4]2[cH:9][cH:8][cH:7][cH:6][cH:5]2)=O)[cH:16][cH:15]1)([CH3:13])[CH3:12]

Participants

9

Reactant 3

HCID 23577Tert-Butyl isocyanideHCID 210413085-Bromo-2-tert-butylpyridineHCID 178419779HCID 178419779, compound

Product 1

HCID 178440944HCID 178440944, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalystHCID 11618717Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-3dd753b024ff4916890e5d6bea637b2d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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