Tert-butyl 2-hydroxyacetate → HCID 178429104, compound

HRID 2012243Notes

Reaction equation

HRID 2012243 reaction equation
[CH3:1][c:2]1[n:7][n:5]([CH3:6])[c:4](Br)[cH:3]1.[CH3:8][C:9]([O:12][C:13]([CH2:15][OH:16])=[O:14])([CH3:11])[CH3:10]>>[CH3:1][c:2]1[n:7][n:5]([CH3:6])[c:4]([O:16][CH2:15][C:13]([O:12][C:9]([CH3:11])([CH3:10])[CH3:8])=[O:14])[cH:3]1

Participants

8

Reactant 2

HCID 11815394Tert-butyl 2-hydroxyacetateHCID 217240315-Bromo-1,3-dimethyl-1H-pyrazole

Product 1

HCID 178429104HCID 178429104, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalystHCID 11618717Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-fee0335ff6254a7b88125d4f4860ea7a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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