Tert-butyl 2-hydroxyacetate → HCID 178429104, compound

HRID 2012244Notes

Reaction equation

HRID 2012244 reaction equation
[CH3:1][C:2]([O:5][C:6]([CH2:8][OH:9])=[O:7])([CH3:4])[CH3:3].[CH3:10][c:11]1[n:16][n:14]([CH3:15])[c:13](Br)[cH:12]1>>[CH3:10][c:11]1[n:16][n:14]([CH3:15])[c:13]([O:9][CH2:8][C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[cH:12]1

Participants

8

Reactant 2

HCID 11815394Tert-butyl 2-hydroxyacetateHCID 217240315-Bromo-1,3-dimethyl-1H-pyrazole

Product 1

HCID 178429104HCID 178429104, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalystHCID 11547931BippyPhosCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-f944ca9707e549aeb8de703791f2abbd
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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