6-Bromoquinoline → Quinoline-6-sulfonic acid

HRID 2012681Notes

Reaction equation

HRID 2012681 reaction equation
CC(Nc1ccc(N(S(F)(=O)=O)[S:2](F)(=[O:4])=[O:3])cc1)=[O:1].Br[c:5]1[cH:14][c:13]([c:8]2[cH:7][cH:6]1)[cH:12][cH:11][cH:10][n:9]2>>[OH:1][S:2]([c:5]1[cH:14][c:13]([c:8]2[cH:7][cH:6]1)[cH:12][cH:11][cH:10][n:9]2)(=[O:4])=[O:3]

Participants

8

Reactant 2

HCID 792436-BromoquinolineHCID 1362129244-(Acetylamino)phenyl]imidodisulfuryl difluoride

Product 1

HCID 316975Quinoline-6-sulfonic acid

Reagents, catalysts & solvents 5

HCID 583616Cesium pivalateReagentHCID 167845palladium(II) acetateCatalystHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)CatalystHCID 679Dimethyl SulfoxideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-3fd03ad71b0c4056991ed2968f121c60
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…