1-Methylimidazole → HCID 178480578, compound

HRID 2013721Notes

Reaction equation

HRID 2013721 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:22][CH2:21][CH:11]([CH2:12][O:13][c:14]2[c:19]([NH2:20])[n:18][cH:17][c:16](Br)[cH:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:23][n:24]1[cH:28][n:27][cH:26][cH:25]1>>[CH3:23][n:24]1[c:28]([c:16]2[cH:15][c:14]([O:13][CH2:12][CH:11]3[CH2:21][CH2:22][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9][CH2:10]3)[c:19]([NH2:20])[n:18][cH:17]2)[n:27][cH:26][cH:25]1

Participants

8

Reactant 2

HCID 13901-MethylimidazoleHCID 121409255Tert-butyl 4-{[(2-amino-5-bromopyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

Product 1

HCID 178480578HCID 178480578, compound

Reagents, catalysts & solvents 5

HCID 23702041Potassium acetate hydrateReagentHCID 80271Tri-o-tolylphosphineCatalystHCID 167845palladium(II) acetateCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-c38c27f0d5654e288cdd0644670ec6cf
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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