4-Methyl-7H-pyrrolo(2,3-d)pyrimidine → HCID 178435032, compound

HRID 2015350Notes

Reaction equation

HRID 2015350 reaction equation

C[c:1]1[c:9]([c:5]2[n:4][cH:3][n:2]1)[cH:8][cH:7][nH:6]2.[CH3:10][c:11]1[c:27](I)[c:26]([c:13]2[s:12]1)[n:25][cH:24][c:15]([NH:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[n:14]2>>[CH3:10][c:11]1[c:27]([n:6]2[c:5]([c:9]3[cH:8][cH:7]2)[n:4][cH:3][n:2][c:1]3Cl)[c:26]([c:13]4[s:12]1)[n:25][cH:24][c:15]([NH:16][CH2:17][c:18]5[cH:23][cH:22][cH:21][cH:20][cH:19]5)[n:14]4

Participants

8

Reactant 2

HCID 513419594-Methyl-7H-pyrrolo(2,3-d)pyrimidine

HCID 178435031HCID 178435031, compound

Product 1

HCID 178435032HCID 178435032, compound

Reagents, catalysts & solvents 5

HCID 2733832Lithium HexamethyldisilazideReagent

HCID 167845palladium(II) acetateCatalyst

HCID 117064351(R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyli-tert-butylphosphineCatalyst

HCID 1140TolueneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-558d078a38ce4c89b9d3a125116bf2a9
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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