Hydrochloric Acid → Methyl 1-({5-[5-(3-fluoro-4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-4-methyl-2-thienyl}methyl)azetidine-3-carboxylate

HRID 201575Notes

Reaction equation

HRID 201575 reaction equation
[C:28]([Br:29])([Br:30])([Br:31])[Br:32].[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[ClH:52].[F:1][c:2]1[cH:3][c:4](-[c:15]2[n:16][c:17](-[c:20]3[c:21]([CH3:27])[cH:22][c:23]([CH2:25][OH:26])[s:24]3)[n:18][o:19]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[NH:53]1[CH2:54][CH:55]([C:57](=[O:58])[O:59][CH3:60])[CH2:56]1.[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1>>[F:1][c:2]1[cH:3][c:4](-[c:15]2[n:16][c:17](-[c:20]3[c:21]([CH3:27])[cH:22][c:23]([CH2:25][N:53]4[CH2:54][CH:55]([C:57](=[O:58])[O:59][CH3:60])[CH2:56]4)[s:24]3)[n:18][o:19]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 81531DiisopropylethylamineHCID 20132751Methyl azetidine-3-carboxylateHCID 68525640{5-[5-(3-Fluoro-4-phenoxyphenyl]-1,2,4-oxadiazol-3-yl)-4-methyl-2-thienyl}methanol

Product 1

HCID 68525875Methyl 1-({5-[5-(3-fluoro-4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-4-methyl-2-thienyl}methyl)azetidine-3-carboxylate

Sources & evidence

ORD record
ord-a2a1019c578043eb834c325ee23e445f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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