Quinoline-3-boronic acid → HCID 178421590, compound

HRID 2016919Notes

Reaction equation

HRID 2016919 reaction equation

OB([c:1]1[cH:10][c:9]([c:4]2[n:3][cH:2]1)[cH:8][cH:7][cH:6][cH:5]2)O.[CH3:11][C@@:12]1([c:19]2[c:24]([OH:25])[n:23][c:22](Cl)[cH:21][cH:20]2)[C:17](=[O:18])[NH:16][CH2:15][CH2:14][CH2:13]1>>[CH3:11][C@@:12]1([c:19]2[c:24]([OH:25])[n:23][c:22]([c:1]3[cH:10][c:9]([c:4]4[n:3][cH:2]3)[cH:8][cH:7][cH:6][cH:5]4)[cH:21][cH:20]2)[C:17](=[O:18])[NH:16][CH2:15][CH2:14][CH2:13]1

Participants

9

Reactant 2

HCID 2734663Quinoline-3-boronic acid

HCID 178421611HCID 178421611, compound

Product 1

HCID 178421590HCID 178421590, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagent

HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylReagent

HCID 522689Potassium FluorideReagent

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalyst

HCID 1140TolueneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-022fbda786fb42e88538cdf76fe5e3d5
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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