Bis(pinacolato)diborane → HCID 131748360, compound

HRID 2017024Notes

Reaction equation

HRID 2017024 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:22][CH2:21][CH:11]([CH2:12][O:13][c:14]2[c:19]([NH2:20])[n:18][cH:17][c:16](Br)[cH:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:23][C:24]1([C:29]([CH3:31])([CH3:30])[O:28][B:27](B2OC(C)(C)C(C)(C)O2)[O:26]1)[CH3:25]>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:22][CH2:21][CH:11]([CH2:12][O:13][c:14]2[c:19]([NH2:20])[n:18][cH:17][c:16]([B:27]3[O:28][C:29]([CH3:31])([CH3:30])[C:24]([CH3:25])([CH3:23])[O:26]3)[cH:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

7

Reactant 2

HCID 2733548Bis(pinacolato)diboraneHCID 121409255Tert-butyl 4-{[(2-amino-5-bromopyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

Product 1

HCID 131748360HCID 131748360, compound

Reagents, catalysts & solvents 4

HCID 10796Cesium carbonateReagentHCID 86278421[1,1'-bis(di-tert-butylphosphino) ferrocene]dichloropalladium(II)CatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-f073eed49a234f189726575ac4b49944
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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