2,4,5-Trichloropyrimidine → HCID 178451679, compound

HRID 2017576Notes

Reaction equation

HRID 2017576 reaction equation
[Cl:1][c:2]1[n:8][c:7](Cl)[c:5]([Cl:6])[cH:4][n:3]1.[K+].[CH3:9][C:10]([O:13][C:14]([N:16]1[CH:20]([B-](F)(F)F)[CH2:19][CH2:18][CH2:17]1)=[O:15])([CH3:12])[CH3:11]>>[CH3:9][C:10]([O:13][C:14]([N:16]1[CH:20]([c:7]2[c:5]([Cl:6])[cH:4][n:3][c:2]([Cl:1])[n:8]2)[CH2:19][CH2:18][CH2:17]1)=[O:15])([CH3:12])[CH3:11]

Participants

8

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 74787601Potassium (1-((tert-butoxy)carbonyl)pyrrolidin-2-yl)trifluoroboranuide

Product 1

HCID 178451679HCID 178451679, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 517044Potassium AcetateReagentHCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)CatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-d48840f1d9d84212b80092880db1516b
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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