4-(4,6-Dichloropyrimidin-2-yl)morpholine → HCID 59507478, compound

HRID 2017828Notes

Reaction equation

HRID 2017828 reaction equation
Cl[c:1]1[n:7][c:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[n:5][c:3]([Cl:4])[cH:2]1.CC1(C(C)(C)OB([c:14]2[cH:20][n:19][c:17]([NH2:18])[n:16][cH:15]2)O1)C>>[NH2:18][c:17]1[n:19][cH:20][c:14]([c:1]2[n:7][c:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[n:5][c:3]([Cl:4])[cH:2]2)[cH:15][n:16]1

Participants

9

Reactant 2

HCID 27720684-(4,6-Dichloropyrimidin-2-yl)morpholineHCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

Product 1

HCID 59507478HCID 59507478, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 516892Sodium BicarbonateReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Sources & evidence

ORD record
ord-954d1588475c4f51bd6902a612ba0098
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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