(R)-(+)-1-Boc-3-aminopyrrolidine → HCID 178452029, compound

HRID 2017841Notes

Reaction equation

HRID 2017841 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:11]([NH2:12])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].Br[c:14]1[cH:19][n:18][c:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[cH:16][cH:15]1>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:11]([NH:12][c:14]2[cH:19][n:18][c:17]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[cH:16][cH:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

7

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 109667244-(5-bromopyridin-2-yl)morpholine

Product 1

HCID 178452029HCID 178452029, compound

Reagents, catalysts & solvents 4

HCID 2733832Lithium HexamethyldisilazideReagentHCID 167845palladium(II) acetateCatalyst2×HCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-65cee7301f0840098180eb382028286a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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