2-Amino-4-bromopyridine → 2-(2-Aminopyridin-4-yl)-4-chlorophenol

HRID 2017945Notes

Reaction equation

HRID 2017945 reaction equation

[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4](Br)[cH:3]1.OB([c:8]1[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]1)O>>[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4]([c:8]2[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]2)[cH:3]1

Participants

8

Reactant 2

HCID 6932822-Amino-4-bromopyridine

HCID 23005362(5-Chloro-2-hydroxyphenyl)boronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 1360636192-(2-Aminopyridin-4-yl)-4-chlorophenol

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 516892Sodium BicarbonateReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 8028TetrahydrofuranSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-8f0d6951797340b0a1f92848979ba296
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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