2-Amino-4-bromopyridine → HCID 136387753, compound

HRID 2017985Notes

Reaction equation

HRID 2017985 reaction equation
[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4](Br)[cH:3]1.OB([c:8]1[c:13]([OH:14])[cH:12][cH:11][c:10]([C:15]([F:18])([F:17])[F:16])[cH:9]1)O>>[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4]([c:8]2[c:13]([OH:14])[cH:12][cH:11][c:10]([C:15]([F:18])([F:17])[F:16])[cH:9]2)[cH:3]1

Participants

9

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 59436609(2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid

Product 1

HCID 136387753HCID 136387753, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-2428781e71e144a69306b3661d9d42d5
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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