Bis(pinacolato)diborane → HCID 89816526, compound

HRID 2018120Notes

Reaction equation

HRID 2018120 reaction equation
[CH3:1][O:2][C:3]([c:5]1[c:11]([C@H:12]([O:14][c:15]2[c:20]([NH2:21])[n:19][cH:18][c:17](Br)[cH:16]2)[CH3:13])[cH:10][c:8]([F:9])[cH:7][cH:6]1)=[O:4].[CH3:22][N:23]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:24][c:25]1[c:30](Br)[cH:29][c:28]([S:31]([CH3:34])(=[O:33])=[O:32])[cH:27][cH:26]1.CC1(C(C)(C)OB(B2OC(C)(C)C(C)(C)O2)O1)C>>[CH3:1][O:2][C:3]([c:5]1[c:11]([C@H:12]([O:14][c:15]2[c:20]([NH2:21])[n:19][cH:18][c:17]([c:30]3[c:25]([CH2:24][N:23]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH3:22])[cH:26][cH:27][c:28]([S:31]([CH3:34])(=[O:33])=[O:32])[cH:29]3)[cH:16]2)[CH3:13])[cH:10][c:8]([F:9])[cH:7][cH:6]1)=[O:4]

Participants

10

Reactant 3

HCID 2733548Bis(pinacolato)diboraneHCID 89807923HCID 89807923, compoundHCID 89808256Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro-, methyl ester

Product 1

HCID 89816526HCID 89816526, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 14798Sodium HydroxideReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-ae62baa7bff44235994376c42f566592
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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