Diboron tetrahydroxide → 1-Methyl-1H-benzoimidazole-6-boronic acid

HRID 2018460Notes

Reaction equation

HRID 2018460 reaction equation
[CH3:1][n:2]1[c:10]([c:5]2[n:4][cH:3]1)[cH:9][c:8](Br)[cH:7][cH:6]2.[OH:11][B:12](B(O)O)[OH:13]>>[CH3:1][n:2]1[c:10]([c:5]2[n:4][cH:3]1)[cH:9][c:8]([B:12]([OH:13])[OH:11])[cH:7][cH:6]2

Participants

7

Reactant 2

HCID 10986154Diboron tetrahydroxideHCID 235376446-Bromo-1-methyl-1H-benzimidazole

Product 1

HCID 467386791-Methyl-1H-benzoimidazole-6-boronic acid

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 167845palladium(II) acetateCatalyst2×HCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-8763c818932a46eda3905f88a4fdf394
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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