2-Bromopyridine → HCID 178480659, compound

HRID 2018551Notes

Reaction equation

HRID 2018551 reaction equation
[CH3:1][N:2]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:20]3[c:19]([n:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[cH:22][cH:21]3)[n:18][c:10]([NH:11][c:12]4[cH:17][n:15]([CH3:16])[n:14][cH:13]4)[n:9]2)[CH2:4]1.Br[c:39]1[n:44][cH:43][cH:42][cH:41][cH:40]1>>[CH3:1][N:2]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:20]3[c:19]([n:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[cH:22][cH:21]3)[n:18][c:10]([N:11]([c:39]4[n:44][cH:43][cH:42][cH:41][cH:40]4)[c:12]5[cH:17][n:15]([CH3:16])[n:14][cH:13]5)[n:9]2)[CH2:4]1

Participants

7

Reactant 2

HCID 79732-BromopyridineHCID 178480801HCID 178480801, compound

Product 1

HCID 178480659HCID 178480659, compound

Reagents, catalysts & solvents 4

HCID 2733832Lithium HexamethyldisilazideReagentHCID 178479583HCID 178479583, compoundCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-0de064ab979a4dc692ff61864665e535
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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