Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 178480791, compound

HRID 2018604Notes

Reaction equation

HRID 2018604 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:15][C@@H:14]([C@H:10]2[CH2:9]1)[CH2:13][NH:12][CH2:11]2)=[O:7])([CH3:4])[CH3:3].[CH3:16][n:17]1[n:31][cH:30][c:19]([NH:20][c:21]2[c:29]([c:25]3[n:24][c:23](Cl)[n:22]2)[n:28][cH:27][nH:26]3)[cH:18]1>>[CH3:16][n:17]1[n:31][cH:30][c:19]([NH:20][c:21]2[c:29]([c:25]3[n:24][c:23]([N:12]4[CH2:11][C@@H:10]([C@H:14]5[CH2:13]4)[CH2:9][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:15]5)[n:22]2)[n:28][cH:27][nH:26]3)[cH:18]1

Participants

7

Reactant 2

HCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 178480784HCID 178480784, compound

Product 1

HCID 178480791HCID 178480791, compound

Reagents, catalysts & solvents 4

HCID 2733832Lithium HexamethyldisilazideReagentHCID 2734558Bis(tri-tert-butylphosphine)palladium(0)CatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-d59ed0c647564c9faf36893ce43c2b3a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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