Bis(pinacolato)diborane → HCID 178498021, compound

HRID 2018753Notes

Reaction equation

HRID 2018753 reaction equation
[CH3:1][O:2][C:3]([c:5]1[c:11]([CH:12]([O:14][c:15]2[c:20]([NH2:21])[n:19][cH:18][c:17](Br)[cH:16]2)[CH3:13])[cH:10][c:8]([F:9])[cH:7][cH:6]1)=[O:4].[CH3:22][N:23]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:24][c:25]1[n:30]([CH3:31])[n:29][c:27]([CH3:28])[c:26]1Br.CC1(C(C)(C)OB(B2OC(C)(C)C(C)(C)O2)O1)C>>[CH3:1][O:2][C:3]([c:5]1[c:11]([CH:12]([O:14][c:15]2[c:20]([NH2:21])[n:19][cH:18][c:17]([c:26]3[c:25]([CH2:24][N:23]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH3:22])[n:30]([CH3:31])[n:29][c:27]3[CH3:28])[cH:16]2)[CH3:13])[cH:10][c:8]([F:9])[cH:7][cH:6]1)=[O:4]

Participants

9

Reactant 3

HCID 2733548Bis(pinacolato)diboraneHCID 89808256Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro-, methyl esterHCID 89816348HCID 89816348, compound

Product 1

HCID 178498021HCID 178498021, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 14798Sodium HydroxideReagentHCID 167845palladium(II) acetateCatalystHCID 887MethanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b8be70dbb3d049cb8f088476ce4b4618
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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