Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → Tert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylate
Reaction equation
[NH2:1][c:2]1[c:7](I)[cH:6][n:5][cH:4][n:3]1.[CH3:8][C:9]([O:12][C:13]([N:15]1[CH2:22][CH2:21][CH:18]([CH2:19][OH:20])[CH2:17][CH2:16]1)=[O:14])([CH3:11])[CH3:10]>>[CH3:8][C:9]([O:12][C:13]([N:15]1[CH2:22][CH2:21][CH:18]([CH2:19][O:20][c:7]2[c:2]([NH2:1])[n:3][cH:4][n:5][cH:6]2)[CH2:17][CH2:16]1)=[O:14])([CH3:11])[CH3:10]Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 120 °C
Sources & evidence
- ORD record
- ord-9e033ba7ff2f41b09ea44a5f5e367239
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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