Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → Tert-butyl 4-{[(4-aminopyrimidin-5-yl)oxy]methyl}piperidine-1-carboxylate
Reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:15][CH2:14][CH:11]([CH2:12][OH:13])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[NH2:16][c:17]1[c:22](Br)[cH:21][n:20][cH:19][n:18]1>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:15][CH2:14][CH:11]([CH2:12][O:13][c:22]2[c:17]([NH2:16])[n:18][cH:19][n:20][cH:21]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 120 °C
Sources & evidence
- ORD record
- ord-af069de279a04e6fa661f066fb544fee
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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