N-ethyltetrahydro-2H-pyran-4-amine → HCID 178463224, compound

HRID 2018822Notes

Reaction equation

HRID 2018822 reaction equation
[CH3:1][c:2]1[n:29][c:20]([O:21][CH2:22][c:23]2[cH:28][cH:27][cH:26][cH:25][cH:24]2)[c:6]([CH2:7][N:8]3[C:18](=[O:19])[c:17]([c:11]4[CH2:10][CH2:9]3)[c:15]([Cl:16])[c:14](OS(C(F)(F)F)(=O)=O)[cH:13][cH:12]4)[c:4]([CH3:5])[cH:3]1.[CH3:30][CH2:31][NH:32][CH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH3:30][CH2:31][N:32]([c:14]1[c:15]([Cl:16])[c:17]([c:11]2[cH:12][cH:13]1)[C:18](=[O:19])[N:8]([CH2:7][c:6]3[c:20]([O:21][CH2:22][c:23]4[cH:28][cH:27][cH:26][cH:25][cH:24]4)[n:29][c:2]([CH3:1])[cH:3][c:4]3[CH3:5])[CH2:9][CH2:10]2)[CH:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5

Participants

8

Reactant 2

HCID 10964527N-ethyltetrahydro-2H-pyran-4-amineHCID 178425082HCID 178425082, compound

Product 1

HCID 178463224HCID 178463224, compound

Reagents, catalysts & solvents 5

HCID 10796Cesium carbonateReagentHCID 167845palladium(II) acetateCatalystHCID 634876Binap, (A+-)-CatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-87a7dbd3299a4af1ae5b7a78204c6d85
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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