1,4-Dimethyl-1H-1,2,3-triazole → 5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one
Reaction equation
[Cl:1][c:2]1[c:13]([c:7]2[c:5]([Br:6])[cH:4][c:3]1I)[C:11](=[O:12])[NH:10][CH2:9][CH2:8]2.[CH3:14][c:15]1[n:20][n:19][n:17]([CH3:18])[cH:16]1>>[CH3:14][c:15]1[c:16]([c:3]2[c:2]([Cl:1])[c:13]([c:7]3[c:5]([Br:6])[cH:4]2)[C:11](=[O:12])[NH:10][CH2:9][CH2:8]3)[n:17]([CH3:18])[n:19][n:20]1Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 110 °C
Sources & evidence
- ORD record
- ord-cc70292b1bda45769db795cc9f788936
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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