Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate
Reaction equation
[F:1][c:2]1[c:8]([CH:9]=[O:10])[c:6]([F:7])[cH:5][c:4](Br)[cH:3]1.[CH3:11][O:12][C:13]([CH:15]=[CH2:16])=[O:14]>>[CH3:11][O:12][C:13](\[CH:15]=[CH:16]\[c:4]1[cH:3][c:2]([F:1])[c:8]([CH:9]=[O:10])[c:6]([F:7])[cH:5]1)=[O:14]Participants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 100 °C
Sources & evidence
- ORD record
- ord-a085a5639ad14c168ee024040b5c9811
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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