Bicarbonate Ion → N-[4-({2-[(cyclopropylcarbonyl)amino]-3-methylimidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 202564Notes

Reaction equation

HRID 202564 reaction equation
[C:77](=[O:78])([O-:79])[OH:80].[CH3:82][N:83]([CH3:84])[CH:85]=[O:86].[CH3:87][CH2:88][O:89][C:90](=[O:91])[CH3:92].[CH:44]([N:45]([CH2:46][CH3:47])[CH:48]([CH3:49])[CH3:50])([CH3:51])[CH3:52].[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:18])[c:10]([C:15](=[O:16])[OH:17])[cH:11][cH:12][c:13]2[CH3:14])[cH:6][cH:7]1.[NH2:19][c:20]1[cH:21][c:22]([F:43])[c:23]([O:24][c:25]2[cH:26][cH:27][c:28]3[n:29]([cH:30]2)[c:31]([CH3:40])[c:32]([NH:34][C:35](=[O:36])[CH:37]2[CH2:38][CH2:39]2)[n:33]3)[cH:41][cH:42]1.[Na+:81].[P-:53]([F:54])([F:55])([F:56])([F:57])([F:58])[F:59].[n:60]1([O:61][C:62]([N:63]([CH3:64])[CH3:65])=[N+:66]([CH3:67])[CH3:68])[c:69]2[n:70][cH:71][cH:72][cH:73][c:74]2[n:75][n:76]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[c:9](=[O:18])[c:10]([C:15](=[O:17])[NH:19][c:20]3[cH:21][c:22]([F:43])[c:23]([O:24][c:25]4[cH:26][cH:27][c:28]5[n:29]([cH:30]4)[c:31]([CH3:40])[c:32]([NH:34][C:35](=[O:36])[CH:37]4[CH2:38][CH2:39]4)[n:33]5)[cH:41][cH:42]3)[cH:11][cH:12][c:13]2[CH3:14])[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 210815291-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acidHCID 58158557N-[6-(4-amino-2-fluorophenoxy)-3-methylimidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Product 1

HCID 58158545N-[4-({2-[(cyclopropylcarbonyl)amino]-3-methylimidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-9703c75be22547f9abc5ec1390b39211
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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