Cesium fluoride → tert-butyl (3R)-3-[(4-bromo-3-fluorobenzoyl)(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate

HRID 2029138Notes

Reaction equation

HRID 2029138 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([N:14]([c:24]2[c:29]([Cl:30])[cH:28][cH:27][cH:26][n:25]2)[C:15]([c:17]3[cH:23][c:22](I)[c:20]([Br:21])[cH:19][cH:18]3)=[O:16])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[F-].[Cs+].[F:31][Ag]>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([N:14]([c:24]2[c:29]([Cl:30])[cH:28][cH:27][cH:26][n:25]2)[C:15]([c:17]3[cH:23][c:22]([F:31])[c:20]([Br:21])[cH:19][cH:18]3)=[O:16])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

7

Reactant 3

HCID 25953Cesium fluorideHCID 62656Caswell No. 736HCID 178451960HCID 178451960, compound

Product 1

HCID 121276864tert-butyl (3R)-3-[(4-bromo-3-fluorobenzoyl)(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate

Reagents, catalysts & solvents 3

HCID 178479583HCID 178479583, compoundCatalystHCID 73012-MethyltetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-57a816b1d38043d19aff4f507b56fc5d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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