Cesium fluoride → tert-butyl (3R)-3-[(4-bromo-3-fluorobenzoyl)(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate

HRID 2029169Notes

Reaction equation

HRID 2029169 reaction equation
[F:1][Ag].[F-].[Cs+].[CH3:2][C:3]([O:6][C:7]([N:9]1[CH2:14][C@H:13]([N:15]([c:25]2[c:30]([Cl:31])[cH:29][cH:28][cH:27][n:26]2)[C:16]([c:18]3[cH:24][c:23](I)[c:21]([Br:22])[cH:20][cH:19]3)=[O:17])[CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4]>>[CH3:2][C:3]([O:6][C:7]([N:9]1[CH2:14][C@H:13]([N:15]([c:25]2[c:30]([Cl:31])[cH:29][cH:28][cH:27][n:26]2)[C:16]([c:18]3[cH:24][c:23]([F:1])[c:21]([Br:22])[cH:20][cH:19]3)=[O:17])[CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4]

Participants

7

Reactant 3

HCID 25953Cesium fluorideHCID 62656Caswell No. 736HCID 178451960HCID 178451960, compound

Product 1

HCID 121276864tert-butyl (3R)-3-[(4-bromo-3-fluorobenzoyl)(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate

Reagents, catalysts & solvents 3

HCID 178420574HCID 178420574, compoundCatalystHCID 73012-MethyltetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-ddc270413d2c47f0a2598e44160b036d
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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