Hydrochloric Acid → 4-(2,3-Dihydro-1-benzofuran-4-ylamino)-8-methyl-7-(methylthio)-3-quinolinecarboxamide

HRID 203111Notes

Reaction equation

HRID 203111 reaction equation
[C:30](=[O:31])([O-:32])[O-:33].[CH3:27][S-:28].[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[Cl:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([NH:17][c:18]3[cH:19][cH:20][cH:21][c:22]4[c:23]3[CH2:24][CH2:25][O:26]4)[c:8]([C:14](=[O:15])[NH2:16])[cH:9][n:10][c:11]2[c:12]1[CH3:13].[ClH:1].[Cu:42][I:43].[K+:34].[K+:35].[Na+:29].[OH2:36]>>[c:3]1([S:28][CH3:27])[cH:4][cH:5][c:6]2[c:7]([NH:17][c:18]3[cH:19][cH:20][cH:21][c:22]4[c:23]3[CH2:24][CH2:25][O:26]4)[c:8]([C:14](=[O:15])[NH2:16])[cH:9][n:10][c:11]2[c:12]1[CH3:13]

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 519392MercaptomethanideHCID 577632127-Chloro-4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methylquinoline-3-carboxamide

Product 1

HCID 577632464-(2,3-Dihydro-1-benzofuran-4-ylamino)-8-methyl-7-(methylthio)-3-quinolinecarboxamide

Sources & evidence

ORD record
ord-23521a38fa0f4c1fb2f488ebc691d1c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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