Tetrahydrofuran → HCID 178421235, compound

HRID 203256Notes

Reaction equation

HRID 203256 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:2][Si:3]([N-:4][Si:5]([CH3:6])([CH3:7])[CH3:8])([CH3:9])[CH3:10].[CH:11]1([C:14]#[CH:15])[CH2:12][CH2:13]1.[Cl:16][c:17]1[cH:18][c:19]([C:37]([C:38]([F:39])([F:40])[F:41])=[O:42])[c:20]([NH:23][C:24](=[O:25])[C:26]23[O:27][C:28](=[O:36])[C:29]([CH3:35])([CH2:30][CH2:31]2)[C:32]3([CH3:33])[CH3:34])[cH:21][cH:22]1.[Li+:1]>>[CH:11]1([C:14]#[C:15][C:37]([c:19]2[cH:18][c:17]([Cl:16])[cH:22][cH:21][c:20]2[NH:23][C:24](=[O:25])[C:26]23[O:27][C:28](=[O:36])[C:29]([CH3:35])([CH2:30][CH2:31]2)[C:32]3([CH3:33])[CH3:34])([C:38]([F:39])([F:40])[F:41])[OH:42])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 138823CyclopropylacetyleneHCID 3280088Npc316347HCID 50916661N-[4-chloro-2-(2,2,2-trifluoroacetyl)phenyl]-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxamide

Product 1

HCID 178421235HCID 178421235, compound

Sources & evidence

ORD record
ord-541cfdd56449439da9769043fa4dbd61
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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