反应详情

温度

180 °C

To 60 mg of 6-chloro-4-(cyclohexylamino)pyridine-3-carboxyamide (the compound of Example 339) suspended in 0.5 mL of diphenyl ether, 84 mg of 4-morpholinoaniline and 23 mg of methanesulfonic acid were added, and stirred at 180° C. for 30 minutes. After cooling, the reaction mixture was dissolved in chloroform, washed with saturated sodium bicarbonate in water, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography (chloroform:methanol=40:1 to 20:1) to obtain 77 mg (82%) of the title compound as a light brown crystalline powder.

1. temperatureAfter cooling
2. washwashed with saturated sodium bicarbonate in water
3. dry with materialdried on anhydrous sodium sulfate
4. customThe solvent was evaporated
5. customthe residue was purified by silica gel column chromatography (chloroform:methanol=40:1 to 20:1)