反应详情

温度

100 °C

25 mg of 4-benzylamino-6-chloropyridine-3-carboxyamide (the compound of Example 1) was dissolved in 0.5 ml of toluene, to which 13.5 mg of 4-aminopyridine, 2 mg of palladium (II) acetate, 248 mg of potassium carbonate and 11 mg of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl were added, and stirred at 100° C. for 28 hours. After cooling, the insoluble substances were filtered off, the filtered product was washed with toluene, combined with the filtrate, and the solvent was evaporated. The residue obtained was purified by silica gel column chromatography (chloroform:methanol=10:1) to obtain 4.8 mg (yield 16%) of the title compound as a slight yellow crystalline powder.

1. additionwere added
2. temperatureAfter cooling
3. filtrationthe insoluble substances were filtered off
4. washthe filtered product was washed with toluene
5. customthe solvent was evaporated
6. customThe residue obtained
7. customwas purified by silica gel column chromatography (chloroform:methanol=10:1)