1,2-Dichloroethane → Tert-butyl 5-fluoro-4-hydroxy-3-[2-(2-oxo-1-pyridinyl)propanoylamino]pentanoate

HRID 203620Notes

Reaction equation

HRID 203620 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[O:17][C:18]([CH2:19][CH:20]([CH:21]([CH2:22][F:23])[OH:24])[NH2:25])=[O:26].[CH2:37]([Cl:38])[CH2:39][Cl:40].[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH3:41][N:42]([c:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1)[CH3:49].[O:1]=[c:2]1[n:3]([CH:8]([C:9](=[O:10])[OH:11])[CH3:12])[cH:4][cH:5][cH:6][cH:7]1.[OH:27][n:28]1[c:29]2[n:30][cH:31][cH:32][cH:33][c:34]2[n:35][n:36]1>>[O:1]=[c:2]1[n:3]([CH:8]([C:9](=[O:11])[NH:25][CH:20]([CH2:19][C:18]([O:17][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:26])[CH:21]([CH2:22][F:23])[OH:24])[CH3:12])[cH:4][cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 8028TetrahydrofuranHCID 142844-(Dimethylamino)pyridineHCID 181649HOAtHCID 108566723-Amino-5-fluoro-4-hydroxy-pentanoic acid tert-butyl esterHCID 167879002-(2-Oxopyridin-1(2H)-yl)propanoic acid

Product 1

HCID 66650000Tert-butyl 5-fluoro-4-hydroxy-3-[2-(2-oxo-1-pyridinyl)propanoylamino]pentanoate

Sources & evidence

ORD record
ord-1bd18292b27a4ff5b13825251a9aff90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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