1,3-Dibromopropane → 9-(3-Bromopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine

HRID 2036309Notes

Reaction equation

HRID 2036309 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[NH:19]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+].[Br:31][CH2:32][CH2:33][CH2:34]Br>CN(C)C=O>[Br:31][CH2:32][CH2:33][CH2:34][N:19]1[C:18]([O:22][CH3:23])=[N:17][C:16]2[C:20]1=[N:21][C:13]([O:12][CH2:8][CH2:9][CH2:10][CH3:11])=[N:14][C:15]=2[NH2:24]

Participants

5

Reactant 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 178450370HCID 178450370, compound

Product 1

HCID 231584909-(3-Bromopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Example 2-1 step (v) (2 g), potassium carbonate (3.7 g) and 1,3-dibromopropane (2.85 ml) were added to dimethylformamide (5 ml), and the same manner to Example 2-13 step (i) was conducted to give the titled compound as a white solid. Yield: 1.0 g (50%).

Sources & evidence

ORD record
ord-25c9ee374af8463eb1f40604ffbb103d
Source dataset
uspto-grants-2013_11
Patent number
US08575180B2

Reaction notes

Loading…