反应详情

温度

0 °C

A mixture of 10 g methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride, 10 ml triethylamine, and 15 ml dichloromethane with 525 mg DMAP is stirred at 0° C. and 9.3 ml of benzyl chloroformate are added dropwise. After stirring overnight at ambient temperature, the reaction mixture is added to cold water. The organic phase is washed, dried, and evaporated. The crude product is purified by a silica gel chromatography.

1. stirringAfter stirring overnight at ambient temperature
2. washThe organic phase is washed
3. customdried
4. customevaporated
5. customThe crude product is purified by a silica gel chromatography