反应详情

To a mixture of 3-hydroxy-2-hydroxymethyl-2-methylpropionic acid (6.71 g, 50 mmol), dimethoxypropane (7.99 mL, 65 mmol) and acetone (50 mL), p-toluenesulfonic acid hydrate (0.048 g, 0.25 mmol) was added and the resulting mixture was stirred at room temperature for 2.5 hours. After the reaction was completed, sodium bicarbonate (0.1 g) was added to the reaction mixture, and the resulting mixture was stirred at room temperature for 5 minutes and concentrated in vacuo. To the resulting residue was added water and the resulting mixture was extracted with ethyl ether. The extract was dried over anhydrous sodium sulphate and concentrated in vacuo to give 2,2,5-trimethyl-1,3-dioxane5-carboxylic acid (7.87 g, yield: 90%) as colorless oil.

1. additionwas added
2. stirringthe resulting mixture was stirred at room temperature for 5 minutes
3. concentrationconcentrated in vacuo
4. additionTo the resulting residue was added water
5. extractionthe resulting mixture was extracted with ethyl ether
6. dry with materialThe extract was dried over anhydrous sodium sulphate
7. concentrationconcentrated in vacuo