Methylamine → HCID 57856004, compound

HRID 2039644Notes

Reaction equation

HRID 2039644 reaction equation
[Cl:1][C:2]1[C:3]2[C:8]([CH:9]=[C:10]3[C:15]=1[N:14]=[C:13]([C:16]1[N:17]([C:25]4[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=4)[N:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:12][C:11]3=[O:32])=[N:7][C:6]([C:33]([F:36])([F:35])[F:34])=[CH:5][CH:4]=2.[CH3:37][NH2:38]>C1COCC1>[CH3:37][NH:38][C:11]([C:10]1[CH:9]=[C:8]2[C:3]([CH:4]=[CH:5][C:6]([C:33]([F:35])([F:34])[F:36])=[N:7]2)=[C:2]([Cl:1])[C:15]=1[NH:14][C:13]([C:16]1[N:17]([C:25]2[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=2)[N:18]=[C:19]([C:21]([F:22])([F:24])[F:23])[CH:20]=1)=[O:12])=[O:32]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57855984HCID 57855984, compound

Product 1

HCID 57856004HCID 57856004, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

9-Chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-6-trifluoromethyl-3-oxa-1,5-diaza-anthracen-4-one is reacted with methylamine in THF analogously to the procedure given in step i) of example H-18. The title product is obtained as yellow crystals after flash column chromatography eluting with 1:1 hexane:ethyl acetate. m.p.: 235-237° C.

Sources & evidence

ORD record
ord-85a77e43d361455c9aaa9329abfc809f
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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