反应详情

In a 100 mL round bottom flask, 1-{2-methoxy-4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone (4.24 g, 14.5 mmol), and glyoxylic acid monohydrate (2.01 g, 21.8 mmol), in acetic acid (20 mL) was heated to reflux 3 h. The reaction was cooled and diluted with water (40 mL). The mixture was basified to pH 8 with NH4OH and then hydrazine monohydrate (1.41 mL, 29.1 mmol) was added. The reaction was heated to reflux 2 h. The reaction was cooled and re-basified with NaHCO3, then extracted with methylene chloride three times. The organics were dried over MgSO4, then ethereal HCL was added. The solvents were removed under vacuum and the product was crystallized with MeOH/ether to produce 500 mg (9%). Mp 182-186° C. MS m/z 344 (M+H).

1. temperatureto reflux 3 h
2. temperatureThe reaction was cooled
3. temperatureThe reaction was heated
4. temperatureto reflux 2 h
5. extractionextracted with methylene chloride three times
6. dry with materialThe organics were dried over MgSO4
7. additionethereal HCL was added
8. customThe solvents were removed under vacuum
9. customthe product was crystallized with MeOH/ether
10. customto produce 500 mg (9%)