Methylamine → HCID 178482447, compound

HRID 2042817Notes

Reaction equation

HRID 2042817 reaction equation
Cl[C:2]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:24][CH2:25][CH:26]([F:28])[F:27])[N:3]=1.[CH3:29][NH2:30]>C1COCC1>[F:27][CH:26]([F:28])[CH2:25][O:24][C:4]1[N:3]=[C:2]([NH:30][CH3:29])[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]=1[C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]1)=[O:7]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178523751HCID 178523751, compound

Product 1

HCID 178482447HCID 178482447, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The subtitle compound is prepared from 6-chloro-2-(2,2-difluoro-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (2.5 g, 5.8 mmol) and CH3NH2 (2 M in THF; 6.0 mL, 12.0 mmol) in THF (25 mL) in analogy with example 1d.

Sources & evidence

ORD record
ord-b0d302e2784f4b33b7d7491625c275f1
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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