Methylamine → HCID 178482444, compound

HRID 2042829Notes

Reaction equation

HRID 2042829 reaction equation
Cl[C:2]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:24][CH2:25][CH2:26][F:27])[N:3]=1.[CH3:28][NH2:29]>C1COCC1>[F:27][CH2:26][CH2:25][O:24][C:4]1[N:3]=[C:2]([NH:29][CH3:28])[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]=1[C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]1)=[O:7]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178523750HCID 178523750, compound

Product 1

HCID 178482444HCID 178482444, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The sub-title compound is prepared from 6-chloro-2-(2-fluoro-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (1.00 g, 2.30 mmol) and methylamine (2 M in THF; 2.75 mL, 5.50 mmol) in THF (15 mL) in analogy with method described in example 1d.

Sources & evidence

ORD record
ord-f58cc54b03fe48dbb495345c05567c7a
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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