Hydrochloric Acid → HCID 178446661, compound

HRID 2043893Notes

Reaction equation

HRID 2043893 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17](O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29]C(C)=CC=O.C([O:37][C:38](=[O:41])CC)C.Cl.CCN(C(C)C)C(C)C>>[CH3:28][C:23]([CH3:24])=[CH:22][CH2:21][N:7]([C@H:1]1[CH2:2][CH2:3][C@H:4]([CH3:29])[CH2:5][CH2:6]1)[C:8](=[O:20])[NH:9][C:10]1[S:11][C:12]([S:15][CH2:16][CH2:17][C:38]([OH:41])=[O:37])=[CH:13][N:14]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 7749Ethyl PropionateHCID 610203-Methyl-2-butenalHCID 81531DiisopropylethylamineHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acid

Product 1

HCID 178446661HCID 178446661, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid, from 4-trans-methyl-cyclohexylamine hydrochloride, 3-methyl-but-2-enal and 2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester. The hydrochloride was added one equivalent DIPEA prior to the reaction.

Workup

  1. customPrepared
  2. customto the reaction

Sources & evidence

ORD record
ord-0a78335a879e4eb2bfa9c067215590a0
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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